Misoprostol helps to decrease risk of serious ulcer complications like bleeding. Learn about side effects, drug interactions, dosages, warnings, and more. Misoprostol is used to decrease the risk of having stomach ulcers in patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin. This medicine works by helping the stomach protect itself against acid damage, and decreases the amount of acid produced by the stomach. Misoprostol is a synthetic prostaglandin E 1 analogue marketed as an oral preparation used to prevent and treat gastroduodenal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs). Misoprostol by mouth is the least effective treatment for producing complete abortion in a period of 24 hours due to the liver's first-pass effect which reduces the bioavailability of the misoprostol. Misoprostol is a very powerful stimulator of uterine contractions in late pregnancy and can cause fetal death and uterine rupture if used in high doses. Follow the dosage regimes carefully and do not exceed those doses. Misoprostol is a medication that can prevent stomach ulcers if you also take NSAID medications. It reduces the amount of acid in your stomach, which protects your stomach lining. Learn about misoprostol (Cytotec) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Find patient medical information for Misoprostol (Cytotec) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Misoprostol is a synthetic prostaglandin that works by replacing prostaglandins whose production is blocked by aspirin or NSAIDs. It is used to prevent stomach ulcers from developing during treatment with aspirin or an NSAID. Misoprostol causes strong cramping and bleeding in the uterus that makes the pregnancy come out through the vagina — similar to a heavy period or early miscarriage.